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1996-03-04
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Document 0714
DOCN M9640714
TI Survival differences in Austrian patients with the acquired
immunodeficiency syndrome.
DT 9604
AU Zangerle R; Reibnegger G; Klein JP; Department of Dermatology and
Venerology, University of; Innsbruck, Austria.
SO Eur J Epidemiol. 1995 Oct;11(5):519-26. Unique Identifier : AIDSLINE
MED/96139645
AB We investigated the association of clinical and demographic factors on
survival of the 901 AIDS cases diagnosed until 31 December 1992 and
reported to the Austrian Health Authorities up to 20 January 1994. The
overall estimated median survival of patients with AIDS increased
substantially from 8 months in 1987 to 16 months in 1988, although this
increase was not significant by the log-rank test. However, the
differences in hazard rates were larger at the beginning of the survival
curve: between 1987 and 1988 the proportion surviving at 1 year
increased from 41 to 62%, compared to an increase of the proportion
surviving at 2 years from 30 to 35% (Breslow test, p value 0.008). AIDS
patients diagnosed between 1988 and 1992 (n = 755) were analyzed in more
detail. Multivariate survival analysis revealed a shorter survival for
those with residence in Eastern Austria, recipients of blood products,
individuals with unknown transmission risk, those presenting with two
AIDS indicator diseases and those with higher age at AIDS diagnosis.
Candidal esophagitis as AIDS indicator disease was associated with
longer survival. One hundred eighty-eight of the 755 AIDS patients
(24.9%) died within the first 3 months after diagnosis of AIDS. We
conclude that the survival time for AIDS patients has improved
considerably after 1987, but survival is still very poor. Several
factors have been shown to predict survival of patients with AIDS in
Austria. Death within the first 3 months after the diagnosis of AIDS
occurred at a relatively high frequency in Austrian AIDS patients. This
may be caused by difficulties in the use of health care facilities or by
the lack of awareness of HIV infection before diagnosis of AIDS either
by patient or care provider.
DE Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION Adolescence
Adult Age Factors Aged Austria/EPIDEMIOLOGY AIDS-Related
Opportunistic Infections/MORTALITY Blood Transfusion/STATISTICS & NUMER
DATA Candidiasis/MORTALITY Comparative Study Disease Notification
Esophagitis/MICROBIOLOGY/MORTALITY Female Forecasting Human HIV
Infections/MORTALITY Logistic Models Male Middle Age Multivariate
Analysis Proportional Hazards Models Residence Characteristics Risk
Factors Survival Analysis Survival Rate Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).